Our Lead Compound: CAR Peptide
Current medical treatments are often limited in their specificity and selectivity. There is a significant unmet medical need for the therapies being developed by VBS Pharmaceuticals that preferentially target diseased tissue in order to minimize unwanted side effects and increase treatment efficacy.
There is a significant unmet need for therapeutics that do not cause further complications for the patient due to harsh side effects.
Our lead therapeutic candidate, CARSKNKDC (CAR) peptide, represents a new paradigm in targeted therapy. CAR preferentially homes to, and penetrates diseased tissue while selectively augmenting the efficacy of therapies. CAR can selectively boost drug effectiveness and reduce systemic side effects by enhancing the targeted uptake of co-administered therapeutics in preclinical models of pulmonary hypertension and triple-negative breast cancer. Additionally, CAR has shown promise in accelerating wound healing, enhancing gene therapy, ameliorating cachexia and in improving sepsis survival.
CAR is a 9-amino-acid cyclic peptide that selectively targets and penetrates diseased tissues by binding to heparan sulfate moieties expressed by cells in injured tissues.
In preclinical animal models, CAR has demonstrated the ability to target hypertensive vessels, fibrotic lesions, areas of inflammation, acute lung injury, asthma, wounds, scars, and tumors, producing an up to 5-fold increase in co-administered drug activity, and a 7-fold increase in gene therapy target gene expression. Furthermore, CAR peptide has demonstrated utility as a stand-alone therapeutic in both sepsis through improving survival rates and in wound healing through producing a 2-fold decrease in wound healing time.
- Learn more about how CAR peptide works
- Current disease applications for CAR peptide
- CAR Peptide Scientific Articles
- For inquiries about CAR peptide and other VBS pharmaceutical products,
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