The Endoarterial Biopsy Catheter
VBS Interventional has developed the endoarterial biopsy catheter for the study, diagnosis, monitoring, and treatment of vascular-based diseases. The endoarterial biopsy catheter will provide physicians with the ability to percutaneously obtain biopsy specimens from the inner layers of the arterial wall. Arterial biopsies can be analyzed using histopathological, genomic and proteomic methods in order to describe current vascular disease status and provide important information about eventual disease progression.
VBS Interventional has recognized this unmet need and created the world’s first endoarterial biopsy catheter, a medical device designed to obtain biopsy specimens from the inner layers of an artery via a minimally invasive technique. The endoarterial biopsy catheter obtains arterial biopsy samples from diseased tissue that can be analyzed using histopathological, genomic and proteomic methods in order to describe current vascular disease status and provide important information about eventual disease progression. This will provide physicians with vital information about each patient’s disease characteristics.
The catheter will provide a means for monitoring therapeutic interventions, optimizing medical management, customizing diagnosis and therapy, and anticipating future adverse events through the early identification of disease markers in arterial biopsies from patients. Information contained in arterial biopsies identifies proteins and receptors involved in vascular-based diseases, which can be used in pharmaceutical drug discovery and development.
The arterial biopsy catheter has successfully and safely obtained endoarterial biopsy samples over 800 times without invasive surgery. Biopsy specimens have been made into histological preparations and examined under a microscope and have also been used as parent tissue for cell cultures. The mRNA levels of biopsy specimens have been quantitated by reverse transcriptase polymerase chain reaction. Single endoarterial biopsy samples have provided sufficient tissue for whole genome microarray analysis.
Potential benefits of the Endoarterial Biopsy Catheter include:
- Minimally invasive non-surgical procedure
- Improved diagnosis of disease
- Earlier intervention, before occurrence of advanced vascular remodeling
- Anticipation and avoidance of future adverse events through the early identification of biomarkers
- Better matching of treatment with disease, customization of therapies
- Pathological monitoring of patient response to therapeutic interventions
- Comprehensive profile of patient’s vascular pathological, cellular, molecular and genetic profile
- Increased patient survival and quality of life
- Decreased patient costs to third-party payers
- More precise patient selection for clinical trial recruitment
- Drug discovery and novel biomarker identification
- Precisely target drugs to specific proteins and receptors found in biopsies of diseased vasculature
- Patient arterial tissue for novel arterial therapies
WARNING: Investigational Device. Limited by Federal law to investigational use. This device should be used only by physicians with a thorough understanding of percutaneous interventional procedures and training in the use of the endoarterial biopsy catheter.
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