Adult wound healing is a complex process involving cellular and biochemical processes including hemostasis, inflammation, proliferation, and remodeling. These processes are tightly correlated and the deregulation of one of them (e.g. significant upregulation of inflammatory response in non-healing chronic wounds such as diabetic ulcers) results in the blocking of the healing process. Advanced wound management usually comprises treatment of chronic wounds in elderly patients. It has been estimated that around 10 to 15 percent of diabetic patients develop diabetic foot ulcers at some point in their lifetime. In addition, the changes in the structure of cell surface heparan sulfate proteoglycans in the sites of injury have been shown to alter the process of wound healing, suggesting that these molecules may play an important role in modulation of cell migration and adhesion facilitating healing. A serious consequence of non-healing wounds is that tissue in the wound bed becomes devitalized, necrotic, or infected. This slows the healing process even more and gives rise to the threat of conditions such as gangrene, which often necessitates amputation.
Our CAR peptide addresses an important unmet need in wound care by providing an orally available wound healing therapeutic that targets altered heparan sulfation patterns at the site of the wound to increase the localized uptake of cytokines, chemokines, and growth factors, which accelerates wound closure. CAR can serve as a homing agent to deliver biological payloads to wounds to reduce scarring. The aging of a large segment of the population and the increase in lifestyle-related diseases such as obesity and diabetes is likely to increase chronic wound incidence, thereby increasing the demand for advanced wound management products.
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